ea0029oc6.6 | Female Reproductioin Basic | ICEECE2012
Miyoshi T.
, Otsuka F.
, Nakamura E.
, Inagaki K.
, Makino H.
Kit ligand (KL)-c-kit interaction is critical for oogenesis and folliculogenesis in the ovary. However, the significance of KL-c-kit loop in ovarian steroidogenesis has yet to be elucidated. We here investigated the impact of KL-c-kit interaction in regulation of steroidogenesis using rat primary granulosa cells co-cultured with oocytes. Treatment with soluble KL suppressed FSH-induced estradiol production and aromatase mRNA expression without changing FSH-induced progesterone...